反应详情

To 40 ml of methanol were added 1.0 g of 6-(3,4-dichlorophenyl)-3(2H)-pyridazinone, 0.2 g of paraformaldehyde and 0.25 g of piperazine, and the resulting mixture was heated under reflux for 2 hours. The mixture was then left to cool, after which insolubles were collected by filtration and dried, to give 1.1 g (yield 88%) of the desired Compound No. 34, melting at 271°-272° C.

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 2 hours
3. waitThe mixture was then left
4. temperatureto cool
5. filtrationafter which insolubles were collected by filtration
6. customdried