Guanidine → HCID 178488157, compound

HRID 649145Notes

Reaction equation

HRID 649145 reaction equation
[NH2:1][C:2]([NH2:4])=[NH:3].[CH3:5][C:6]1[CH:7]=[N:8][C:9]([CH2:15][S+:16]([O-:28])[C:17]2[NH:18][C:19]3[CH:20]=[CH:21][C:22]([O:26][CH3:27])=[CH:23][C:24]=3[N:25]=2)=[C:10]([CH3:14])[C:11]=1[O:12][CH3:13]>C(O)C>[CH3:5][C:6]1[CH:7]=[N:8][C:9]([CH2:15][S+:16]([O-:28])[C:17]2[NH:18][C:19]3[CH:20]=[CH:21][C:22]([O:26][CH3:27])=[CH:23][C:24]=3[N:25]=2)=[C:10]([CH3:14])[C:11]=1[O:12][CH3:13].[NH2:3][C:2]([NH2:4])=[NH2+:1]

Participants

4

Reactant 2

HCID 3520GuanidineHCID 178488147HCID 178488147, compound

Product 1

HCID 178488157HCID 178488157, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of guanidine (0.0029 mol) [prepared from guanidinium nitrate and KOH] in ethanol (50 ml) was added to a solution of omeprazole (1.0 g, 0.0029 mol) and the resulting solution was stirred for 15 min. The solvent was evaporated giving omeprazole guanidinium salt, mp 110°-112° C. (soluble in water).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-44bc33beba564d64aee9f1658ccde6a4
Source dataset
uspto-grants-1988_04
Patent number
US04738974

Reaction notes

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