Ammonium Hydroxide → HCID 13821857, compound

HRID 649163Notes

Reaction equation

HRID 649163 reaction equation
Cl.[Cl:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][N:7]1[C:15]([C:16](Cl)=[O:17])=[C:14]([CH3:19])[N:13]=[C:8]12.[OH-].[NH4+:21]>>[C:16]([C:15]1[N:7]2[CH:6]=[CH:5][C:4]3[C:9]([C:8]2=[N:13][C:14]=1[CH3:19])=[CH:10][CH:11]=[CH:12][C:3]=3[Cl:2])(=[O:17])[NH2:21]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 20142435HCID 20142435, compound

Product 1

HCID 13821857HCID 13821857, compound

Procedure

To 28% ammonium hydroxide (50 ml) was added 7-chloro-3-chloroformyl-2-methylimidazo[2,1-a]isoquinoline hydrochloride (1.3 g) and the mixture was stirred under ice-cooling for 40 minutes. The resulting precipitate was collected by filtration, washed with water and recrystallized from a mixture of chloroform and methanol to give 3-carbamoyl-7-chloro-2-methylimidazo[2,1-a]isoquinoline (0.75 g).

Workup

  1. temperaturecooling for 40 minutes
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customrecrystallized from a mixture of chloroform and methanol

Sources & evidence

ORD record
ord-4a7720ef3e104486ab1adae6d7005021
Source dataset
uspto-grants-1988_04
Patent number
US04738967

Reaction notes

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