反应详情

A mixture of 1-amino-5-chloroisoquinoline (6.1 g), ethyl 2-acetyl-2-bromoacetate (10.75 g) and sodium bicarbonate (14.36 g) in ethanol (72 ml) was refluxed for 2 hours and then filtered by suction. The filtrate was evaporated in vacuo, and the residue was dissolved in a mixture of chloroform and methanol. The solution was treated with silica gel (10 g) and filtered by suction. The filtrate was evaporated in vacuo and the residue was recrystallized from ethanol to give 7-chloro-3-ethoxycarbonyl-2-methylimidazo[2,1-a]isoquinoline (5.83 g).

1. temperaturewas refluxed for 2 hours
2. filtrationfiltered by suction
3. customThe filtrate was evaporated in vacuo
4. dissolutionthe residue was dissolved in a mixture of chloroform and methanol
5. additionThe solution was treated with silica gel (10 g)
6. filtrationfiltered by suction
7. customThe filtrate was evaporated in vacuo
8. customthe residue was recrystallized from ethanol