反应详情

To a solution of 2-[(3,4-dimethoxypyrid-2-yl)methylthio]benzimidazole (1.08 g) in methylene chloride (30 ml) was added m-chloroperbenzoic acid (0.79 g) in small protions below 10° C. After completion of the reaction the reaction, the mixture was diluted with methylene chloride (70 ml), washed with an aqueous solution of potassium carbonate and then with water, dried, and evaporated. The residue was purified by column chromatography on silica gel (chloroform-methanol (40:1)) and crystallized from acetone-ether, to give 2-[(3,4-dimethoxypyrid-2-yl)methylsulfinyl]benzimidazole (670 mg) as light brown crystals. m.p. 149°-151° C. (decomposed).

1. customAfter completion of the reaction
2. customthe reaction
3. washwashed with an aqueous solution of potassium carbonate
4. dry with materialwith water, dried
5. customevaporated
6. customThe residue was purified by column chromatography on silica gel (chloroform-methanol (40:1))
7. customcrystallized from acetone-ether