HCID 20142115, compound → HCID 20142156, compound

HRID 649247Notes

Reaction equation

HRID 649247 reaction equation
[CH2:1]([NH:6][C:7](=[O:31])[CH2:8][NH:9][C:10](=[O:30])[CH:11]([N:19]([O:22]CC1C=CC=CC=1)[CH:20]=[O:21])[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:2][CH:3]([CH3:5])[CH3:4].C(O)CCC.CC(O)=O.O>CO.CC(O)=O.O.[Pd]>[CH2:1]([NH:6][C:7](=[O:31])[CH2:8][NH:9][C:10](=[O:30])[CH:11]([N:19]([OH:22])[CH:20]=[O:21])[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:2][CH:3]([CH3:5])[CH3:4]

Participants

5

Reactant 2

HCID 20142115HCID 20142115, compoundHCID 22056973Butanol acetic acid water

Product 1

HCID 20142156HCID 20142156, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 86607755Acetic acid methanol waterSolvent

Procedure

127 mg of the compound of Example 31 are dissolved in 3 ml of the mixture CH3OH/AcOH/H2O, 4/5/1 and hydrogenated at ordinary pressure in the presence of 30 mg of 10% Pd/C. After 1 hour, the theoretical volume is absorbed or filtered, and concentrated to dryness giving a white solid. W 88 mg. Rdt 88%; Rf 0.85; BuOH/AcOH/H2O, 4/1/1/.

Workup

  1. customthe theoretical volume is absorbed
  2. filtrationfiltered
  3. concentrationconcentrated to dryness
  4. customgiving a white solid

Sources & evidence

ORD record
ord-251827cdf1a6422cab5575174169b718
Source dataset
uspto-grants-1988_04
Patent number
US04738803

Reaction notes

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