Hydrochloric Acid → HCID 86742110, compound

HRID 649281Notes

Reaction equation

HRID 649281 reaction equation
C([O:3][C:4]([C:6]1[C:7](=[O:19])[C:8]2[CH2:16][C:15](=[N:17][OH:18])[S:14][C:9]=2[N:10]([CH2:12][CH3:13])[CH:11]=1)=[O:5])C.Cl>O.[OH-].[Na+]>[CH2:12]([N:10]1[CH:11]=[C:6]([C:4]([OH:5])=[O:3])[C:7](=[O:19])[C:8]2[CH2:16][C:15](=[N:17][OH:18])[S:14][C:9]1=2)[CH3:13]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86742109HCID 86742109, compound

Product 1

HCID 86742110HCID 86742110, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

In 10 ml of water containing 0.4 g of sodium hydroxide was dissolved 0.125 g (0.42 mmol) of 4,7-dihydro-7-ethyl-2-hydroxyimino-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester, anti-isomer. The solution obtained was maintained under stirring at room-temperature for 1 hour and then acidified with concentrated hydrochloric acid. The precipitate obtained was filtered out, washed with water and then with alcohol. After drying, 4,7-dihydro-7-ethyl-2-hydroxyimino-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid, anti-isomer was obtained in a yield of 98%.

Workup

  1. customThe solution obtained
  2. temperaturewas maintained
  3. customThe precipitate obtained
  4. filtrationwas filtered out
  5. washwashed with water
  6. customAfter drying

Sources & evidence

ORD record
ord-d375aacb1c684eb5a99c6dee8c0bb0d3
Source dataset
uspto-grants-1988_04
Patent number
US04739065

Reaction notes

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