Hydrochloric Acid → HCID 54048413, compound

HRID 649282Notes

Reaction equation

HRID 649282 reaction equation
C([O:3][C:4]([C:6]1[C:7](=[O:22])[C:8]2[CH2:16][C:15](=[N:17]C(OC)=O)[S:14][C:9]=2[N:10]([CH2:12][CH3:13])[CH:11]=1)=[O:5])C.[OH-:23].[Na+].Cl>O>[CH2:12]([N:10]1[CH:11]=[C:6]([C:4]([OH:3])=[O:5])[C:7](=[O:22])[C:8]2[CH2:16][C:15](=[N:17][O:23][CH2:6][C:4]([OH:5])=[O:3])[S:14][C:9]1=2)[CH3:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70415872HCID 70415872, compound2×

Product 1

HCID 54048413HCID 54048413, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To the solution obtained in Example V containing 4,7-dihydro-7-ethyl-2-carbomethoxyimino-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester was added 0.15 g (3.7 mmols) of sodium hydroxide in 5 ml of water. The medium was maintained under stirring for 3 hours at room-temperature. The precipitate formed was filtered out, washed with ethanol and then with ethyl ether. The product so obtained was then taken up in 20 ml of water and the solution was acidified with concentrated hydrochloric acid. The precipitate so formed was filtered out, washed with water and then with ethanol. After drying, 4,7-dihydro-7-ethyl-2-carboxymethoxyimino-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid was obtained in a yield of 40%.

Workup

  1. temperatureThe medium was maintained
  2. customThe precipitate formed
  3. filtrationwas filtered out
  4. washwashed with ethanol
  5. customThe product so obtained
  6. customThe precipitate so formed
  7. filtrationwas filtered out
  8. washwashed with water
  9. customAfter drying

Sources & evidence

ORD record
ord-25531672a24644359232fe5acf81523a
Source dataset
uspto-grants-1988_04
Patent number
US04739065

Reaction notes

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