Methanol → HCID 14809493, compound

HRID 649310Notes

Reaction equation

HRID 649310 reaction equation
Cl[C:2]1([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[OH:22])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1.[CH3:23][OH:24]>>[OH:22][C:15]1[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:2]1([O:24][CH3:23])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1

Participants

3

Reactant 2

HCID 887MethanolHCID 14809492HCID 14809492, compound

Product 1

HCID 14809493HCID 14809493, compoundYield 85.3%

Procedure

A mixture of 2-chloro-3,4-dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (14.0 g, compound No. 3) and methanol (200 ml) is stirred for 2 hours at room temperature, and the separated crystals are collected by filtration to give 11.8 g (85.3%) of the titled compound.

Workup

  1. filtrationthe separated crystals are collected by filtration

Sources & evidence

ORD record
ord-8dc0d765e6054906b9896044b16b1db3
Source dataset
uspto-grants-1988_04
Patent number
US04739050

Reaction notes

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