Methanethiol → HCID 14809494, compound

HRID 649311Notes

Reaction equation

HRID 649311 reaction equation
Cl[C:2]1([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[OH:22])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1.[CH3:23][SH:24]>O1CCCC1>[OH:22][C:15]1[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:2]1([S:24][CH3:23])[C:7](=[O:8])[N:6]([CH3:9])[C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[S:3]1

Participants

4

Reactant 2

HCID 878MethanethiolHCID 14809492HCID 14809492, compound

Product 1

HCID 14809494HCID 14809494, compoundYield 78.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Chloro-3,4-dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-3-oxo-2H-1,4-benzothiazine (12.3 g, compound No. 3) is added to a mixture of 30% aqueous methyl mercaptan solution (26 ml) and tetrahydrofuran (50 ml). The mixture is stirred for 1.5 hours at room temperature and concentrated in vacuo. The separated crystals are collected by filtration to give 10.0 g (78.3%) of the titled compound.

Workup

  1. concentrationconcentrated in vacuo
  2. filtrationThe separated crystals are collected by filtration

Sources & evidence

ORD record
ord-e7ac83adb3084309bbc6d48504431d6f
Source dataset
uspto-grants-1988_04
Patent number
US04739050

Reaction notes

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