Tert-Butylamine → HCID 20143104, compound

HRID 649319Notes

Reaction equation

HRID 649319 reaction equation
[C:1]([C:3]1([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH:23]3[O:25][CH2:24]3)=[CH:17][CH:16]=2)[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[S:4]1)#[N:2].[C:26]([NH2:30])([CH3:29])([CH3:28])[CH3:27]>C(O)C>[C:26]([NH:30][CH2:24][CH:23]([OH:25])[CH2:22][O:21][C:18]1[CH:17]=[CH:16][C:15]([C:3]2([C:1]#[N:2])[C:8](=[O:9])[N:7]([CH3:10])[C:6]3[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=3[S:4]2)=[CH:20][CH:19]=1)([CH3:29])([CH3:28])[CH3:27]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 20143001HCID 20143001, compound

Product 1

HCID 20143104HCID 20143104, compoundYield 74.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred suspension of 2-cyano-3,4-dihydro-2-[4-(2,3-epoxypropoxy)phenyl]-4-methyl-3-oxo-2H-1,4-benzothiazine (1.2 g, compound No. 23) in ethanol (15 ml), tert-butylamine (3.6 ml) is added. The mixture is refluxed for 1.5 hours, and concentrated in vacuo to give 1.3 g (74.8%) of the titled compound.

Workup

  1. additionis added
  2. temperatureThe mixture is refluxed for 1.5 hours
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1750eb5d812c4bf0b7b84e4d93fb3566
Source dataset
uspto-grants-1988_04
Patent number
US04739050

Reaction notes

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