Hydrochloric Acid → HCID 20143085, compound

Participants

Reaction Steps

To a stirred suspension of 2-(4-acetoxyphenyl)-2-(N-acetylmethylamino)-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzothiazine (3.2 g, compound No. 70) in tetrahydrofuran (20 ml), a mixture of 2N sodium hydroxide (20.8 ml) and tetrahydrofuran (20 ml) is added. The mixture is stirred for 20 minutes at room temperature and poured into 2N hydrochloric acid. The separated crystals are collected by filtration to give 2.6 g (91.6%) of the titled compound.

Provenance & Evidence