Hydrochloric Acid → HCID 20143085, compound

HRID 649327Notes

Reaction equation

HRID 649327 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2([NH:23][CH2:24][C:25](=[O:27])[CH3:26])[C:16](=[O:17])[N:15]([CH3:18])[C:14]3[CH:19]=[CH:20][CH:21]=[CH:22][C:13]=3[S:12]2)=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+].Cl>O1CCCC1>[C:25]([CH2:24][NH:23][C:11]1([C:8]2[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=2)[C:16](=[O:17])[N:15]([CH3:18])[C:14]2[CH:19]=[CH:20][CH:21]=[CH:22][C:13]=2[S:12]1)(=[O:27])[CH3:26]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20143056HCID 20143056, compound

Product 1

HCID 20143085HCID 20143085, compoundYield 91.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a stirred suspension of 2-(4-acetoxyphenyl)-2-(N-acetylmethylamino)-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzothiazine (3.2 g, compound No. 70) in tetrahydrofuran (20 ml), a mixture of 2N sodium hydroxide (20.8 ml) and tetrahydrofuran (20 ml) is added. The mixture is stirred for 20 minutes at room temperature and poured into 2N hydrochloric acid. The separated crystals are collected by filtration to give 2.6 g (91.6%) of the titled compound.

Workup

  1. additionis added
  2. filtrationThe separated crystals are collected by filtration

Sources & evidence

ORD record
ord-a7895036a18e401d8f1fac3f922b4398
Source dataset
uspto-grants-1988_04
Patent number
US04739050

Reaction notes

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