反应详情

To a 0° solution of 2.2 mole of methyl magnesium iodide in 1.5 l. ether is added a solution of 200 g. (1.06 mole) of methyl 3-benzyloxybenzoate in 500 ml. ether and 500 ml. tetrahydrofuran. The reaction mixture is stirred for 3 hours and then added to 1.5 l. ice cold saturated ammonium chloride and 2 l. ether. The organic extract is dried over magnesium sulfate and evaporated to an oil. Crystallization of the crude oil in petroleum ether gives 186 g. (93%) of the title compound.

1. customTo a 0°
2. additionadded to 1.5 l
3. extractionThe organic extract
4. dry with materialis dried over magnesium sulfate
5. customevaporated to an oil
6. customCrystallization of the crude oil in petroleum ether
7. customgives 186 g