反应详情

In a mixture of 200 ml of ethyl acetate and 12 g of pyridine is dissolved 11.5 g of ethyl 4-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxybutyrate, and 5 ml of thionyl chloride is added to the solution, followed by refluxing with stirring for 1 hour. After cooling, 500 ml of water and 100 ml are added to the reaction solution, followed by extraction. The extract is washed with 0.1N hydrochloric acid and water successively, dried over anhydrous magnesium sulfate and treated with activated carbon. The ethyl acetate is evaporated off to give 10.5 g of ethyl 4-(1-benzyloxycarbonyl-4-piperidyl)-2-chlorobutyrate pale yellow oil.

1. additionis added to the solution
2. temperatureby refluxing
3. temperatureAfter cooling
4. extractionfollowed by extraction
5. washThe extract is washed with 0.1N hydrochloric acid and water successively
6. dry with materialdried over anhydrous magnesium sulfate
7. additiontreated with activated carbon
8. customThe ethyl acetate is evaporated off