反应详情

In 40 ml of ethanol is dissolved 26 g of ethyl 6-(1-benzyloxycarbonyl-4-piperidyl)-2-oxohexanoate, and 6.2 g of acetic acid is added to the solution. Sodium cyanoborohydride (4.4 g) is added to the mixture under ice-cooling, and the mixture is stirred for 1 hour and allowed to stand at room temperature overnight. Water (500 ml) is added to the reaction solution, followed by extraction with methylene chloride. The extract is dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting brown viscous material is purified by silica-gel column chromatography (hexane:ethyl acetate=2:1) to give 16 g of ethyl 6-(1-benzyloxycarbonyl-4-piperidyl)-2-hydroxyhexanoate as a colorless oily material.

1. additionis added to the solution
2. temperaturecooling
3. waitto stand at room temperature overnight
4. extractionfollowed by extraction with methylene chloride
5. dry with materialThe extract is dried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe resulting brown viscous material is purified by silica-gel column chromatography (hexane:ethyl acetate=2:1)