Ammonia → 2-cyano-2-phenylacetamide

HRID 649427Notes

Reaction equation

HRID 649427 reaction equation
[C:1]([CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4](OC)=[O:5])#[N:2].[NH3:14]>C1C=CC=CC=1>[C:1]([CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([NH2:14])=[O:5])#[N:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 10866842HCID 10866842, compound

Product 1

HCID 2235872-cyano-2-phenylacetamideYield 75%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A 10% solution of methyl 2-cyano-2-phenylacetate in benzene is saturated with ammonia under ice cooling. The reaction mixture is allowed to stand at room temperature for 2 hours, and then the product is filtered off. 2-Cyano-2-phenylacetic acid amide is obtained with a yield of 75%; m.p.: 148.5°-150° C.

Workup

  1. filtrationthe product is filtered off

Sources & evidence

ORD record
ord-fbe203fd70f64ea5ae552f9b04e0a270
Source dataset
uspto-grants-1988_04
Patent number
US04740228

Reaction notes

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