Hydrochloric Acid → HCID 86742121, compound

HRID 649511Notes

Reaction equation

C([N:4]1[C:18]2[C:19]3[CH:6]([CH2:7][C@@H:8]4[C:13]([C:14]=3[C:15]([Br:20])=[CH:16][CH:17]=2)=[CH:12][C@H:11]([NH:21][C:22](=[O:28])[N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])[CH2:10][N:9]4[CH3:29])[CH2:5]1)(=O)C.Cl>>[Br:20][C:15]1[C:14]2=[C:19]3[C:18]([NH:4][CH2:5][C@H:6]3[CH2:7][C@@H:8]3[C:13]2=[CH:12][C@H:11]([NH:21][C:22](=[O:28])[N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])[CH2:10][N:9]3[CH3:29])=[CH:17][CH:16]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86742122HCID 86742122, compound

Product 1

HCID 86742121HCID 86742121, compound

Procedure

This compound is obtained--analogously to Example 7--from 3-(1-acetyl-12-bromo-9,10-didehydro-2,3-dihydro-6-methyl-8α-ergolinyl)-1,1-diethylurea by heating with 1N hydrochloric acid.

Workup

customThis compound is obtained

Sources & evidence

ORD record: ord-37826beffdeb41068901197e41760705
Source dataset: uspto-grants-1988_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04740509

Reaction notes

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