Pyridine → HCID 54049001, compound

HRID 649552Notes

Reaction equation

HRID 649552 reaction equation
[Br:1][CH2:2][C:3](=[N:9][OH:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:11](Cl)(=[O:15])[C:12]([CH3:14])=[CH2:13].N1C=CC=CC=1>C(Cl)Cl>[Br:1][CH2:2][C:3](=[N:9][O:10][C:11](=[O:15])[C:12]([CH3:14])=[CH2:13])[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

5

Reactant 3

HCID 1049PyridineHCID 13528Methacryloyl chlorideHCID 53428735Ethyl 3-bromo-2-(hydroxyimino)propanoate

Product 1

HCID 54049001HCID 54049001, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Ethyl 3-bromo-2-(hydroxyimino)propanoate (4.0 g, 19 mmole) and methacryloyl chloride (2.18 g, 20.8 mmole) in methylene chloride (100 ml) were treated with dry pyridine (1.66 g, 21 mmole). After a workup as in Example 1, 4.42 g (84% yield) of ethyl 3-bromo-2-(methacryloyloximino)propanoate was obtained as an oil. NMR and IR spectra confirm the structure.

Sources & evidence

ORD record
ord-ac52329a796c4772b5ffb2519b5a7c34
Source dataset
uspto-grants-1988_04
Patent number
US04740524

Reaction notes

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