反应详情

To a stirred suspension of ethyl 4-hydroxy-6-oxo-5,6,7,8-tetrahydroquinoline 3-carboxylate (12 g) in 250 mL of THF, 35 mL of 3N MeMgBr in Et2O is added dropwise under cooling maintaining the temperature at 0° to 5°. The mixture is stirred for another 1 hour at the same temperature, then quenched and evaporated. The dried residue is taken up in CHCl3 washed with aqueous NaCl, dried (MgSO4) and evaporated to obtain ethyl 4,6-dihydroxy-6-methyl-5,6,7,8-tetrahydroquinoline-3-carboxylate.

1. additionis added dropwise
2. temperatureunder cooling
3. temperaturemaintaining the temperature at 0° to 5°
4. customquenched
5. customevaporated
6. washwashed with aqueous NaCl
7. dry with materialdried (MgSO4)
8. customevaporated