Hydrochloric Acid → HCID 21243251, compound

HRID 649640Notes

Reaction equation

HRID 649640 reaction equation
Cl.[C:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][C:21]2[C:24]3[CH:30]=[CH:29][CH:28]=[CH:27][C:25]=3[O:26][C:20]=2[CH2:19]1)([OH:4])=[O:3].[CH2:31](O)[CH3:32]>>[CH2:31]([O:3][C:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][C:21]2[C:24]3[CH:30]=[CH:29][CH:28]=[CH:27][C:25]=3[O:26][C:20]=2[CH2:19]1)=[O:4])[CH3:32]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 21243293HCID 21243293, compound

Product 1

HCID 21243251HCID 21243251, compound

Procedure

HCl is passed for 2 hours into a solution of 3.88 g of 2-[4-(5-carboxy-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine in 50 ml of absolute ethanol. The mixture is then allowed to stand at 20° for 48 hours, the usual working up is carried out, and 2-[4-(5-ethoxycarbonyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine is obtained.

Sources & evidence

ORD record
ord-60f7e25b83ac4ca1b1fe8287846a44d0
Source dataset
uspto-grants-1988_04
Patent number
US04740602

Reaction notes

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