反应详情

A mixture of 5-hydroxy-12H-benzo[a]phenothiazine (5 g) and α-chloroethyl chloroformate (10 g) in tetrahydrofuran (20 ml) was refluxed for 9 hours, then the volatile components were evaporated away and the residue chromatographed on a column of silica gel, eluting with a 1:9 ethyl acetate-hexane mixture to afford the title compound (4 g) as an oil.

1. temperaturewas refluxed for 9 hours
2. customthe volatile components were evaporated away
3. customthe residue chromatographed on a column of silica gel
4. washeluting with a 1:9 ethyl acetate-hexane mixture