Imidazole → N-[2-(3-imidazol-1-ylpropoxy)-4-nitrophenyl]acetamide

HRID 649713Notes

Reaction equation

HRID 649713 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:7]=1[NH:15][C:16](=[O:18])[CH3:17].[NH:19]1[CH:23]=[CH:22][N:21]=[CH:20]1>CN(C)C=O>[N:19]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:7]=2[NH:15][C:16](=[O:18])[CH3:17])[CH:23]=[CH:22][N:21]=[CH:20]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 18003912N-(2-(3-Chloropropoxy)-4-nitrophenyl)acetamide

Product 1

HCID 21713252N-[2-(3-imidazol-1-ylpropoxy)-4-nitrophenyl]acetamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

54.5 g (0.2 mol) of N-[2-(3-chloropropoxy)-4-nitrophenyl]acetamide, the preparation of which was described in step a) of Example 6 above, and 40.8 g (0.6 mol) of 1H imidazole in 150 ml of dimethylformamide were heated on a boiling water bath for 4 hours.

Workup

  1. temperaturewere heated on a boiling water bath for 4 hours

Sources & evidence

ORD record
ord-4bf144c21f234e2091ad091fb12d1027
Source dataset
uspto-grants-2001_08
Patent number
US06270533B1

Reaction notes

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