Triethylamine → HCID 53677822, compound

HRID 649836Notes

Reaction equation

HRID 649836 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[F:23][C:24]1[CH:32]=[CH:31][CH:30]=[CH:29][C:25]=1[C:26](Cl)=[O:27]>ClCCl>[C:1]([O:5][C:6](=[O:7])[NH:8][C:9]1[CH:10]=[CH:11][C:12]([NH:15][C:26](=[O:27])[C:25]2[CH:29]=[CH:30][CH:31]=[CH:32][C:24]=2[F:23])=[CH:13][CH:14]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 98082-Fluorobenzoyl chlorideHCID 688611tert-Butyl (4-aminophenyl)carbamate

Product 1

HCID 53677822HCID 53677822, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of mono-N-(t-butoxycarbonyl)-1,4-phenylenediamine (1.58 g) and triethylamine (1.50 mL) in 25 mL of dichloromethane is added o-fluorobenzoyl chloride (1.20 g). A solid formed immediately forms and is filtered and washed with fresh solvent to yield a white solid, 1.90 g.

Workup

  1. customA solid formed immediately forms
  2. filtrationis filtered
  3. washwashed with fresh solvent
  4. customto yield a white solid, 1.90 g

Sources & evidence

ORD record
ord-e817bf00f0c44516a1b71871bfc9499c
Source dataset
uspto-grants-2001_08
Patent number
US06271236B1

Reaction notes

Loading…