反应详情

3-Chloro-4-fluoronitrobenzene (1.0 g) and N,N′-dimethyl-3-aminopyrrolidine (1.72 g) are combined and stirred for approximately 24 hours. The mixture is then diluted with ethyl acetate, washed twice with water and once with saturated sodium chloride, and dried over anhydrous sodium sulfate. After removal of the solvent under reduced pressure the residue is chromatographed over silica gel (pure ethyl acetate followed by pure methanol is used as the eluants) to provide the desired product as a yellow oil.

1. washwashed twice with water and once with saturated sodium chloride
2. dry with materialdried over anhydrous sodium sulfate
3. customAfter removal of the solvent under reduced pressure the residue
4. customis chromatographed over silica gel (pure ethyl acetate