HCID 18422289, compound → HCID 18422238, compound

HRID 649916Notes

Reaction equation

HRID 649916 reaction equation
[N+:1]([C:4]1[CH:24]=[CH:23][CH:22]=[CH:21][C:5]=1[NH:6][C:7]1[S:11][C:10]2[CH:12]=[CH:13][C:14]([CH3:16])=[CH:15][C:9]=2[C:8]=1[C:17]([O:19][CH3:20])=[O:18])([O-])=O.[H][H]>[C].[Pd].C(OCC)(=O)C>[NH2:1][C:4]1[CH:24]=[CH:23][CH:22]=[CH:21][C:5]=1[NH:6][C:7]1[S:11][C:10]2[CH:12]=[CH:13][C:14]([CH3:16])=[CH:15][C:9]=2[C:8]=1[C:17]([O:19][CH3:20])=[O:18]

Participants

5

Reactant 2

HCID 18422289HCID 18422289, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18422238HCID 18422238, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In the same manner as in Starting Material Synthesis Example 19 and using methyl 2-(2-nitroanilino)-5-methylbenzo[b]thiophene-3-carboxylate, ethyl acetate, 10% palladium-carbon and hydrogen (60 atm kg/cm2), methyl 2-(2-aminoanilino)-5-methylbenzo[b]thiophene-3-carboxylate is obtained.

Workup

  1. customMaterial Synthesis Example 19

Sources & evidence

ORD record
ord-a43a99b8df014cff85c734c2d5310c5e
Source dataset
uspto-grants-2001_08
Patent number
US06271225B1

Reaction notes

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