HCID 18422272, compound → HCID 18422381, compound

HRID 649918Notes

Reaction equation

HRID 649918 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:9]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N+:23]([O-])=O)[S:8][C:7]=2[CH:26]=1.[H][H]>[C].[Pd].C(OCC)(=O)C>[NH2:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[NH:16][C:9]1[S:8][C:7]2[CH:26]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=2[C:10]=1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

5

Reactant 2

HCID 18422272HCID 18422272, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18422381HCID 18422381, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In the same manner as in Starting Material Synthesis Example 19 and using ethyl 6-methoxy-2-(2-nitroanilino)benzo[b]thiophene-3-carboxylate, ethyl acetate, 10% palladium-carbon and hydrogen (60 atm kg/cm2), ethyl 2-(2-aminoanilino)-6-methoxybenzo[b]thiophene-3-carboxylate is obtained.

Workup

  1. customMaterial Synthesis Example 19

Sources & evidence

ORD record
ord-512ac53ee0cd425d92c08f04d06dc8a0
Source dataset
uspto-grants-2001_08
Patent number
US06271225B1

Reaction notes

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