HCID 18422166, compound → HCID 18422282, compound

HRID 649919Notes

Reaction equation

HRID 649919 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:25]([O-])=O)=[C:6]([CH:24]=1)[NH:7][C:8]1[S:12][C:11]2[CH:13]=[C:14]([O:17][CH3:18])[CH:15]=[CH:16][C:10]=2[C:9]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20].[H][H]>[C].[Pd].C(OCC)(=O)C>[NH2:25][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:24][C:6]=1[NH:7][C:8]1[S:12][C:11]2[CH:13]=[C:14]([O:17][CH3:18])[CH:15]=[CH:16][C:10]=2[C:9]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]

Participants

5

Reactant 2

HCID 18422166HCID 18422166, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18422282HCID 18422282, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In the same manner as in Starting Material Synthesis Example 19 and using ethyl 2-(5-fluoro-2-nitroanilino)-6-methoxybenzo[b]thiophene-3-carboxylate, ethyl acetate, 10% palladium-carbon and hydrogen (60 atm kg/cm2), ethyl 2-(2-amino-5-fluoroanilino)-6-methoxybenzo[b]thiophene-3-carboxylate is obtained.

Workup

  1. customMaterial Synthesis Example 19

Sources & evidence

ORD record
ord-b891f013d641425392c58ba756de3ace
Source dataset
uspto-grants-2001_08
Patent number
US06271225B1

Reaction notes

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