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Anisole → 3-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Anisole | HCID 7519 | — |
| 反応物 | Ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate | HCID 18422261 | — |
| 触媒 | Titanium Tetrachloride | HCID 24193 | — |
| 溶媒 | 1-Methylpiperazine | HCID 53167 | — |
| 生成物 | 3-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine | HCID 135816403 | — |
反応手順
In the same manner as in Example 1 and using ethyl 2-(2-aminoanilino)-6-methylbenzo[b]thiophene-3-carboxylate (3.7 g), 1-methylpiperazine (80 ml), anisole (16 ml) and titanium tetrachloride (3 ml), 3-methyl-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine (1.4 g) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06271225B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-52bba78a8f5843fa855f333b23871e63 |
| 出典メモ | uspto-grants-2001_08 |