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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 649948Generated: October 30, 2026

2,4-Difluoronitrobenzene → 6-Fluoro-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carbonitrile

https://huagongshe.com/reaction/649948

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DifluoronitrobenzeneHCID 67967—
Reactant2-Amino-6-fluorobenzo[b]thiophene-3-carbonitrileHCID 18422184—
Product6-Fluoro-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carbonitrileHCID 1842226992.4%

Reaction Steps

In the same manner as in Starting Material Synthesis Example 51 and using 2-amino-6-fluorobenzo[b]thiophene-3-carbonitrile (4.9 g) and 2,4-difluoro-nitrobenzene (4.1 g), 6-fluoro-2-(5-fluoro-2-nitroanilino)benzo[b]thiophene-3-carbonitrile (7.8 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06271225B1
Source datasetuspto-grants-2001_08
ORD IDord-75065d156d1447b7b466d39bb2194eaa
Source noteuspto-grants-2001_08