HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → 12-amino-3-fluoro-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,2-Ethanediamine, N1,N1,N2-trimethyl- | HCID 67338 | — |
| Reactant | 12-amino-8-fluoro-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine | HCID 18422385 | — |
| Reactant | 8-fluoro-12-[N-(2-dimethylaminoethyl)-N-methylamino]-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine | HCID 21713591 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 12-amino-3-fluoro-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine | HCID 135816402 | — |
Reaction Steps
In the same manner as in Example 42 and using 12-amino-8-fluoro-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine.1 hydrochloride (1.3 g), N,N,N′-trimethylethylenediamine (13 g), dimethyl sulfoxide (5 ml) and citric acid, 8-fluoro-12-[N-(2-dimethylaminoethyl)-N-methylamino]-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine.1 citrate 1 hydrate (289 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271225B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-7084f4f0d05f4a87880fa8d69e3129bd |
| Source note | uspto-grants-2001_08 |