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HRID649955

反应详情

EQUATION

反应方程式

HRID 649955 的结构方程式

REACTANTS

反应物

5
结构：O=C(O)CC(O)(CC(=O)O)C(=O)O
HCID311

Citric acid

C6H8O7

结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CNCCN(C)C
HCID67338

1,2-Ethanediamine, N,N,N'-trimethyl-

C5H14N2

结构：NC1=Nc2ccc(F)cc2Nc2sc3ccccc3c21
HCID18422385

未命名化合物

结构：CN(C)CCN(C)C1=Nc2ccc(F)cc2Nc2sc3ccccc3c21
HCID21713591

未命名化合物

PRODUCTS

生成物

1
结构：NC1=Nc2ccccc2Nc2sc3cc(F)ccc3c21
HCID135816402

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

In the same manner as in Example 42 and using 12-amino-8-fluoro-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine.1 hydrochloride (1.3 g), N,N,N′-trimethylethylenediamine (13 g), dimethyl sulfoxide (5 ml) and citric acid, 8-fluoro-12-[N-(2-dimethylaminoethyl)-N-methylamino]-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine.1 citrate 1 hydrate (289 mg) was obtained.