1,1-Ethanedithiol → HCID 18422276, compound

HRID 649959Notes

Reaction equation

HRID 649959 reaction equation
[F:1][C:2]1[CH:26]=[C:25]([O:27]C)[C:5]2[N:6]=[C:7]([N:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]3)[C:8]3[C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=4[S:11][C:9]=3[NH:10][C:4]=2[CH:3]=1.C(S)(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>ClCCl>[F:1][C:2]1[CH:26]=[C:25]([OH:27])[C:5]2[N:6]=[C:7]([N:18]3[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]3)[C:8]3[C:13]4[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=4[S:11][C:9]=3[NH:10][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 336451,1-EthanedithiolHCID 6451240Aluminum(III) ChlorideHCID 18422291HCID 18422291, compound

Product 1

HCID 18422276HCID 18422276, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In the same manner as in Example 62 and using 8-fluoro-10-methoxy-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine, dichloromethane, ethanedithiol and aluminium chloride, 8-fluoro-10-hydroxy-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained.

Sources & evidence

ORD record
ord-1ba3d010a510462d97b054c56d062059
Source dataset
uspto-grants-2001_08
Patent number
US06271225B1

Reaction notes

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