Potassium Carbonate → 8-fluoro-2-methylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one

HRID 649996Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:15]=[C:14]([CH3:16])[S:13][C:12]=2Br)=[O:10])=[C:4]([OH:18])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][C:9](=[O:10])[C:11]3[CH:15]=[C:14]([CH3:16])[S:13][C:12]=3[O:18][C:4]=2[CH:3]=1

Participants

Reactant 2

HCID 11430Potassium Carbonate

HCID 18422331N-(4-fluoro-2-hydroxyphenyl)-2-bromo-5-methyl-3-thiophenecarboxamide

Product 1

HCID 184223168-fluoro-2-methylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one

Procedure

Similar reaction is carried out using N-(4-fluoro-2-hydroxyphenyl)-2-bromo-5-methyl-3-thiophenecarboxarnide and potassium carbonate to give 8-fluoro-2-methylthieno[2,3-b][1,5]benzoxazepin-4(5H)-one.

Workup

customSimilar reaction

Sources & evidence

ORD record: ord-dfeca1a4302a4a4bbaf8cdac08c9f790
Source dataset: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06271225B1

Reaction notes

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