Benzo(B)Thiophene-2-Boronic Acid → 2-(4-Methoxyphenyl)benzothiophene

HRID 650022Notes

Reaction equation

HRID 650022 reaction equation
[S:1]1[C:5](B(O)O)=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.Br[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1>>[CH3:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([C:5]2[S:1][C:2]3[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=3[CH:4]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 2359Benzo(B)Thiophene-2-Boronic AcidHCID 77304-Bromoanisole

Product 1

HCID 41373912-(4-Methoxyphenyl)benzothiopheneYield 91%

Procedure

The title compound was prepared in 91% yield from benzo[b]thiophene-2-boronic acid and 4-bromoanisole by using a coupling procedure similar to that described below in Example 14-A.

Sources & evidence

ORD record
ord-b39f83c9b36e4e32b339d1205442fc78
Source dataset
uspto-grants-2001_08
Patent number
US06271227B1

Reaction notes

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