反应详情

温度

60 °C

To a solution of α-(trifluoromethyl)benzylmesylate (2.8 g, 11.0 mmol) in DMF (15 mL), sodium azide (7.38 g, 110 mmol) was added. The reaction mixture was stirred at 60° C. for 48 hours. Then the reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried over MgSO4 and filtered. The solvent was evaporated and chromatography of the resulting solid on silica gel gave the desired product (849 mg, 37%). EI-MS m/z 202 (M+).

1. customThen the reaction mixture was partitioned between ethyl acetate and water
2. dry with materialThe organic layer was dried over MgSO4
3. filtrationfiltered
4. customThe solvent was evaporated