反应详情

Racemic 1-aminoindan (5.7 g, 43 mmole) in ether (20 ml) stirred in ice, was treated dropwise with adipoyl chloride (1.83 g, 10 mmole) in ether (10 ml). After 30 min. the solid was filtered and slurried with water for 45 min. The insoluble solid was collected, air dried (2.82 g) and crystallized from HOAc/H2O, washed with acetic acid/water (1:1), ethanol and ether and then dried to give 2.26 g (60% title compound. Melting point: 227° C.

1. filtrationAfter 30 min. the solid was filtered
2. customThe insoluble solid was collected
3. customair dried (2.82 g)
4. customcrystallized from HOAc/H2O
5. washwashed with acetic acid/water (1:1), ethanol and ether
6. customdried