Phenyl isocyanate → N-[4-(1-cyclopenten-1-yl)-1,3-dimethyl-1H-pyrazol-5-yl]-N'-phenylurea

HRID 65018Notes

Reaction equation

HRID 65018 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:10]1([C:15]2[C:16]([CH3:22])=[N:17][N:18]([CH3:21])[C:19]=2[NH2:20])[CH2:14][CH2:13][CH2:12][CH:11]=1>C1C=CC=CC=1>[C:10]1([C:15]2[C:16]([CH3:22])=[N:17][N:18]([CH3:21])[C:19]=2[NH:20][C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:9])[CH2:14][CH2:13][CH2:12][CH:11]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 133521924-(1-cyclopenten-1-yl)-1,3-dimethyl-1H-pyrazol-5-amine

Product 1

HCID 13352208N-[4-(1-cyclopenten-1-yl)-1,3-dimethyl-1H-pyrazol-5-yl]-N'-phenylurea

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Phenylisocyanate (0.176 mol) is added to 4-(1-cyclopenten-1-yl)-1,3-dimethyl-1H-pyrazol-5-amine (0.16 mol) in benzene (800 ml). The reaction mixture is stirred at room temperature and then at a temperature between 50° and 70° C. After distillation under vacuum, the product of the title is recovered by usual procedures. M.p. 204° C.

Workup

  1. customat a temperature between 50° and 70° C
  2. distillationAfter distillation under vacuum
  3. customthe product of the title is recovered by usual procedures

Sources & evidence

ORD record
ord-8ae964ec380945738e640356bc097d75
Source dataset
uspto-grants-1986_09
Patent number
US04612318

Reaction notes

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