反应详情

A mixture of 4-(1,2,5,6-tetrahydro-1-methyl-4-pyridinyl)-1,3-dimethyl-5-(1H)-pyrazolamine (2.06 g; 0.01 mol), 3,4-lutidine (20 ml), ethyl isocyanate (3.16 ml; 0.04 mol), under anhydrous conditions, are heated to the reflux temperature for about 3 hours. The mixture is then cooled to room temperature, concentrated under reduced pressure, washed with ethyl acetate and then with ethyl ether, thus obtaining the product of the title. M.p. 294°-297° C.

1. temperatureunder anhydrous conditions, are heated to the reflux temperature for about 3 hours
2. concentrationconcentrated under reduced pressure
3. washwashed with ethyl acetate
4. customwith ethyl ether, thus obtaining the product of the title