Hydrochloric Acid → Tetrahydrofolic acid

HRID 650223Notes

Reaction equation

HRID 650223 reaction equation
[C:1]([OH:32])(=[O:31])[CH2:2][CH2:3][C@H:4]([NH:8][C:9]([C:11]1[CH:30]=[CH:29][C:14]([NH:15][CH2:16][C@@H:17]2[NH:28][C:27]3[C:25](=[O:26])[NH:24][C:22]([NH2:23])=[N:21][C:20]=3[NH:19][CH2:18]2)=[CH:13][CH:12]=1)=[O:10])[C:5]([OH:7])=[O:6].Cl>O>[C:1]([OH:32])(=[O:31])[CH2:2][CH2:3][C@H:4]([NH:8][C:9]([C:11]1[CH:12]=[CH:13][C:14]([NH:15][CH2:16][CH:17]2[NH:28][C:27]3[C:25](=[O:26])[NH:24][C:22]([NH2:23])=[N:21][C:20]=3[NH:19][CH2:18]2)=[CH:29][CH:30]=1)=[O:10])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 135398650(6S)-5,6,7,8-tetrahydrofolic acid2×

Product 1

HCID 135444742Tetrahydrofolic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

By dissolving 20 g of the resulting crystalline (6S)-tetrahydrofolic acid in 80 ml of water at pH 9 and subsequently slowly bringing the pH to 5.1 using hydrochloric acid, 4.5 g of crystalline (6S)-tetrahydrofolic acid with a chemical content of 94.0% and a (6S) percentage of 94.7 are obtained after seeding with crystalline (6S)-tetrahydrofolic acid. The water content after drying is 1.8%.

Sources & evidence

ORD record
ord-df7ea9a716e84a09925975e3ae70b0e6
Source dataset
uspto-grants-2001_08
Patent number
US06271374B1

Reaction notes

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