1,4-Dioxane hydrochloride → HCID 21714056, compound

HRID 650247Notes

Reaction equation

HRID 650247 reaction equation
Cl.O1CCOCC1.[CH2:8]([N:11]1[C:16](=[O:17])[C:15]([NH:18]C(OC(C)(C)C)=O)=[CH:14][N:13]=[C:12]1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH:9]=[CH2:10]>CO>[CH2:8]([N:11]1[C:16](=[O:17])[C:15]([NH2:18])=[CH:14][N:13]=[C:12]1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH:9]=[CH2:10]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21714058HCID 21714058, compound

Product 1

HCID 21714056HCID 21714056, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

4 N hydrogen chloride/dioxane (31 ml, 122.2 mmol) was added to a solution of 1-allyl-5-t-butyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine (2 g, 6.11 mmol) in methanol (12 ml) under cooling on ice and stirred at 0° C. for 30 minutes and at room temperature overnight. The reaction solution was concentrated under reduced pressure whereby the title compound (1.49 g, 93%) was obtained as white solid.

Workup

  1. temperatureunder cooling on ice
  2. concentrationThe reaction solution was concentrated under reduced pressure whereby the title compound (1.49 g, 93%)
  3. customwas obtained as white solid

Sources & evidence

ORD record
ord-3b479853840b4d2788f8134e330f9254
Source dataset
uspto-grants-2001_08
Patent number
US06271238B1

Reaction notes

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