1,4-Dioxane hydrochloride → HCID 21714056, compound

Participants

Reaction Conditions

Reaction Steps

4 N hydrogen chloride/dioxane (31 ml, 122.2 mmol) was added to a solution of 1-allyl-5-t-butyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine (2 g, 6.11 mmol) in methanol (12 ml) under cooling on ice and stirred at 0° C. for 30 minutes and at room temperature overnight. The reaction solution was concentrated under reduced pressure whereby the title compound (1.49 g, 93%) was obtained as white solid.

Provenance & Evidence