反应详情

In 40 ml of acetonitrile was dissolved 493 mg of thiopropionic acid amide. In the solution was suspended 2.15 g of 2-bromo-1-(4-methoxyphenyl)-2-(3-pyridyl)ethanone. To the suspension was added dropwise slowly 0.78 ml of triethylamine while stirring. The mixture was stirred for 3 hours at a refluxing temperature, then the solvent was evaporated off. To the residue was added a saturated aqueous solution of sodium hydrogen carbonate. The mixture was subjected to extraction with ethyl acetate. The extract was dried, then the solvent was evaporated off. The residue was recrystallised from ethyl acetate-isopropyl ether to yield 1.38 g (91%) of 2-ethyl-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole, m.p. 59°-60° C.

1. stirringThe mixture was stirred for 3 hours at a refluxing temperature
2. customthe solvent was evaporated off
3. additionTo the residue was added a saturated aqueous solution of sodium hydrogen carbonate
4. extractionThe mixture was subjected to extraction with ethyl acetate
5. customThe extract was dried
6. customthe solvent was evaporated off
7. customThe residue was recrystallised from ethyl acetate-isopropyl ether