Hydrochloric Acid → 2-(Aminomethyl)-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole

Participants

Reaction Conditions

Reaction Steps

In 10 ml of tetrahydrofuran was dissolved 1.2 g of 2-(benzyloxycarbonylaminomethyl)-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole obtained by Example 11. To the solution was added 10 ml of 5N-HCl, and the mixture was stirred for 2 hours at 80° C. Tetrahydrofuran was evaporated off under reduced pressure. The remaining aqueous layer was made alkaline with 2N-NaOH, which was subjected to extraction with ethyl acetate. The extract was washed with water and dried, then the solvent was evaporated off. The residue was purified by means of a silica-gel column chromatography [eluent: chloroform-methanol (9:1)] to give 0.5 g (yield 60%) of 2-(aminomethyl)-4-(4-methoxyphenyl)-5-(3-pyridyl)-1,3-thiazole.

Provenance & Evidence