反应详情

温度

100 °C

5.0 g of 3-chloro-5-trifluoromethyl-2-acetylpyridine (Example P8) are introduced into 30 ml of toluene and 3.60 ml of N,N-dimethylformamide-dimethylacetal are added. The resulting yellow solution is stirred overnight at 100° C. After cooling to 25° C., the mixture is concentrated to dryness in vacuo, yielding 6.17 g of the desired target compound in the form of a dark-yellow oil which later solidifies.

1. additionare added
2. temperatureAfter cooling to 25° C.
3. concentrationthe mixture is concentrated to dryness in vacuo
4. customyielding 6.17 g of the desired target compound in the form of a dark-yellow oil which