Dimethylformamide dimethyl acetal → HCID 1472834, compound

HRID 650480Notes

Reaction equation

HRID 650480 reaction equation
[Cl:1][C:2]1[C:3]([C:12](=[O:14])[CH3:13])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]([C:12](=[O:14])[CH:13]=[CH:17][N:18]([CH3:20])[CH3:19])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 217121361-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-ethanone

Product 1

HCID 1472834HCID 1472834, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
100 °C

Procedure

5.0 g of 3-chloro-5-trifluoromethyl-2-acetylpyridine (Example P8) are introduced into 30 ml of toluene and 3.60 ml of N,N-dimethylformamide-dimethylacetal are added. The resulting yellow solution is stirred overnight at 100° C. After cooling to 25° C., the mixture is concentrated to dryness in vacuo, yielding 6.17 g of the desired target compound in the form of a dark-yellow oil which later solidifies.

Workup

  1. additionare added
  2. temperatureAfter cooling to 25° C.
  3. concentrationthe mixture is concentrated to dryness in vacuo
  4. customyielding 6.17 g of the desired target compound in the form of a dark-yellow oil which

Sources & evidence

ORD record
ord-596ad85d500847b08aa18bc2200b71ea
Source dataset
uspto-grants-2001_08
Patent number
US06274536B1

Reaction notes

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