反应详情

In the same manner as described in Example 8 by using (3R)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline (1.01 g), 2N KOH (2.5 ml), CS2 (0.3 ml), 4-chlorobenzyl chloride (0.81 g) and 70% ethanol (20 ml), there is prepared the title compound (1.34 g, 67%) as white powder, [α]D20 -111.8° (c=1.0, methanol). NMR (CDCl3 -DMSO-d6, δ): 4.56 (s, 2H, CSSCH2C6H4 -p-Cl), Mass m/e: 402 (M+), 244 (M+ -p-Cl-C6H4CH2SH).