HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Disulfide → HCID 13375525, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | (3R)-3-hydroxymethyl-1,2,3,4-tetrahydro-beta-carboline | HCID 13375507 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 13375525 | HCID 13375525 | 67% |
Reaction Steps
In the same manner as described in Example 8 by using (3R)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline (1.01 g), 2N KOH (2.5 ml), CS2 (0.3 ml), 4-chlorobenzyl chloride (0.81 g) and 70% ethanol (20 ml), there is prepared the title compound (1.34 g, 67%) as white powder, [α]D20 -111.8° (c=1.0, methanol). NMR (CDCl3 -DMSO-d6, δ): 4.56 (s, 2H, CSSCH2C6H4 -p-Cl), Mass m/e: 402 (M+), 244 (M+ -p-Cl-C6H4CH2SH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04612317 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-f008ead447c74e179fc8d7c2b9692401 |
| Source note | uspto-grants-1986_09 |