反应详情

In the same manner as described in Example 13 by using (1R, 3R)-3-hydroxymethyl-1-methyl-1,2,3,4-tetrahydro-β-carboline (4.32 g), triethylamine (4.04 g), CS2 (3.04 g), methyl iodide (5.68 g) and 80% ethanol (150 ml), there is prepared the title compound (4.22 g, 69%) as white powder, [α]D20 -205.4° (c=1.0, methanol). NMR (CDCl3, δ): 1.66 (d, J=6.7 Hz, 3H, C1 --CH3), 2.70 (s, 3H, CSSCH3), Mass m/e: 306 (M+), 258 (M+ --CH3SH).