反应详情

In the same manner as described in Example 13 by using (1RS, 3RS)-cis-1-ethyl-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline (1.04 g), triethylamine (2.73 g), CS2 (2.05 g), methyl iodide (3.84 g), methanol (30 ml) and water (3 ml), there is prepared the title compound (940 mg, 65%) as colorless prisms, m.p. 177°-180° C. (recrystallized from ether). NMR (CDCl3, δ): 1.34 (t, J=7.0 Hz, 3H, C1 --CH2CH3), 2.70 (s, 3H, CSSCH3), Mass m/e: 320 (M+), 272 (M+ --CH3SH).

1. customis prepared
2. customthe title compound (940 mg, 65%) as colorless prisms, m.p. 177°-180° C. (recrystallized from ether)