HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 57316763, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | HCID 21712645 | HCID 21712645 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 57316763 | HCID 57316763 | — |
Reaction Steps
A mixture of 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphtalene-2-yl)-ethoxy)-benzaldehyde (350 mg; 1.0 mmol), 2,4-thiazolidinedione (129 mg; 1.1 mmol), piperidine (1 drop) and acetic acid (1 drop) in toluene (10 ml) was refluxed for 3 hours using a water separator. Upon cooling to room temperature the product precipitated. Filtration gave the title compound in 325 mg (72%) yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06274608B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-7fbebacac4834939bd1fe8f297e0f2c1 |
| Source note | uspto-grants-2001_08 |